Nunzio Bottini Selected Research

Protein Tyrosine Phosphatases

1/2021	The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy.
1/2021	Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.
10/2020	RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain.
1/2019	The Contribution of PTPN22 to Rheumatic Disease.
10/2017	PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis.
5/2017	Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets.
2/2016	Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.
12/2015	Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.
1/2014	Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.
7/2013	The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.

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Nunzio Bottini Research Topics

Disease

12	Rheumatoid Arthritis 01/2022 - 09/2007
8	Autoimmune Diseases (Autoimmune Disease) 01/2020 - 09/2007
7	Inflammation (Inflammations) 05/2022 - 03/2009
7	Neoplasms (Cancer) 10/2020 - 07/2002
6	Arthritis (Polyarthritis) 10/2020 - 07/2013
6	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 11/2015 - 04/2004
4	Obesity 01/2021 - 09/2000
3	Fibrosis (Cirrhosis) 01/2022 - 10/2017
3	Insulin Resistance 01/2021 - 10/2009
3	Osteoarthritis 05/2016 - 12/2014
3	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2012 - 08/2005
2	Systemic Scleroderma (Systemic Sclerosis) 01/2022 - 05/2017
2	Hypertrophy 01/2021 - 01/2002
2	Rheumatic Diseases (Rheumatism) 01/2019 - 05/2017
2	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 10/2014 - 09/2007
2	Plague (Bubonic Plague) 03/2005 - 02/2004
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/2020
1	Experimental Arthritis 01/2019
1	Necrosis 01/2016
1	Heart Diseases (Heart Disease) 12/2015
1	Cardiomyopathies (Cardiomyopathy) 12/2015
1	Poisoning 01/2015
1	Carcinogenesis 09/2014
1	Adenoma (Adenomas) 09/2014
1	Infections 01/2014
1	Communicable Diseases (Infectious Diseases) 07/2013
1	Colitis 07/2013
1	Experimental Melanoma 06/2013
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2009
1	Graves Disease (Basedow Disease) 09/2007
1	Vitiligo 09/2007
1	Thyroid Diseases (Thyroid Disease) 08/2005
1	Paralysis (Palsy) 03/2005
1	Hypertriglyceridemia 11/2002
1	Tourette Syndrome (Tourette's Syndrome) 09/2002
1	Lymphoma (Lymphomas) 07/2002
1	Leukemia 07/2002
1	Asthma (Bronchial Asthma) 01/2002
1	Alzheimer Disease (Alzheimer's Disease) 01/2002
1	Hypersensitivity (Allergy) 01/2002
1	Fetal Macrosomia 09/2000

Drug/Important Bio-Agent (IBA)

16	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2022 - 07/2002
14	Protein Tyrosine PhosphatasesIBA 01/2021 - 01/2002
10	Tyrosine (L-Tyrosine)FDA Link 01/2019 - 02/2004
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 09/2000
4	Acid PhosphataseIBA 01/2012 - 09/2002
3	Phosphotransferases (Kinase)IBA 01/2022 - 09/2014
3	src-Family KinasesIBA 10/2020 - 06/2012
3	Phosphates (Orthophosphate)IBA 05/2017 - 07/2002
2	Proteoglycans (Proteoglycan)IBA 01/2022 - 05/2015
2	CytokinesIBA 01/2022 - 01/2014
2	Insulin ReceptorIBA 01/2021 - 01/2021
2	Pharmaceutical PreparationsIBA 05/2017 - 03/2009
2	EnzymesIBA 05/2017 - 06/2013
2	MicroRNAs (MicroRNA)IBA 01/2017 - 11/2013
2	Insulin (Novolin)FDA Link 11/2015 - 10/2009
2	LigandsIBA 01/2014 - 06/2013
1	LipidsIBA 05/2022
1	ChemokinesIBA 01/2022
1	Antifibrotic AgentsIBA 01/2022
1	purineIBA 01/2021
1	Non-Receptor Type 2 Protein Tyrosine PhosphataseIBA 10/2020
1	Tumor Necrosis Factor InhibitorsIBA 01/2020
1	Antirheumatic Agents (DMARD)IBA 01/2020
1	Methotrexate (Mexate)FDA LinkGeneric 01/2019
1	AlbuminsIBA 01/2019
1	Cysteine (L-Cysteine)FDA Link 01/2019
1	Bleomycin (Blenoxane)FDA LinkGeneric 10/2017
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 05/2017
1	Tyrosine Kinase InhibitorsIBA 05/2017
1	Histones (Histone)IBA 01/2017
1	Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA 05/2016
1	Platelet-Derived Growth FactorIBA 01/2016
1	Interleukin-1 (Interleukin 1)IBA 01/2016
1	Botulinum Toxins (Botulinum Toxin)IBA 01/2015
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 09/2014
1	Ion Channels (Ion Channel)IBA 09/2014
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2014
1	TNF Receptor-Associated Factor 3IBA 07/2013
1	Antiviral Agents (Antivirals)IBA 07/2013
1	Inflammation MediatorsIBA 05/2013
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 09/2012
1	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 09/2012
1	Glucose (Dextrose)FDA LinkGeneric 10/2009
1	Biological ProductsIBA 10/2009
1	Biomarkers (Surrogate Marker)IBA 03/2009
1	Adenosine DeaminaseIBA 01/2009
1	Type III Secretion SystemsIBA 03/2005
1	Non-Receptor Type 22 Protein Tyrosine PhosphataseIBA 04/2004
1	Virulence Factors (Pathogenicity Factors)IBA 02/2004
1	Triglycerides (Triacylglycerol)IBA 11/2002
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 07/2002
1	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 07/2002
1	Serine (L-Serine)FDA Link 07/2002
1	Phosphatidylinositols (Phosphatidylinositol)IBA 07/2002

Therapy/Procedure

8	Therapeutics 01/2022 - 03/2011
2	Immunotherapy 06/2013 - 03/2009